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EC 1.14.20.8 Details
EC number
1.14.20.8
Accepted name
(–)-deoxypodophyllotoxin synthase
Reaction
(–)-yatein + 2-oxoglutarate + O2 = (–)-deoxypodophyllotoxin + succinate + CO2 + H2O
Other name(s)
2-ODD (gene name)
Systematic name
(–)-yatein,2-oxoglutarate:oxygen oxidoreductase (ring-forming)
Comment
The enzyme, characterized from the plant Sinopodophyllum hexandrum (mayapple), is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold.
History
created 2016 as EC 1.14.11.50, transferred 2018 to EC 1.14.20.8
EC Tree
1.3.99.9 created 1976, deleted 2002