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EC 4.2.3.97 Details
EC number
4.2.3.97
Accepted name
(-)-δ-cadinene synthase
Reaction
(2E,6E)-farnesyl diphosphate = (-)-δ-cadinene + diphosphate
Systematic name
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-δ-cadinene-forming)
Comment
The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. Following a 1,3-hydride shift of the original 1-pro-S hydrogen of (2E,6E)-farnesyl diphosphate, cyclization and deprotonation gives (-)-δ-cadinene.
History
created 2012
EC Tree
1.3.99.9 created 1976, deleted 2002