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EC 4.2.3.96 Details
EC number
4.2.3.96
Accepted name
avermitilol synthase
Reaction
(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate
Systematic name
avermitilol hydrolase (cyclizing, avermitilol-forming)
Comment
Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained.
History
created 2012
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