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EC 2.3.1.187 Details
EC number
2.3.1.187
Accepted name
acetyl-S-ACP:malonate ACP transferase
Reaction
an acetyl-[acyl-carrier protein] + malonate = a malonyl-[acyl-carrier protein] + acetate
Other name(s)
acetyl-S-ACP:malonate ACP-SH transferase,
acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase,
MdcA,
MadA,
ACP transferase,
malonate/acetyl-CoA transferase,
malonate:ACP transferase,
acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase
Systematic name
acetyl-[acyl-carrier-protein]:malonate S-[acyl-carrier-protein]transferase
Comment
This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue [2]. This enzyme forms the α subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 7.2.4.4). The enzyme can also use acetyl-CoA as a substrate but more slowly [4].
History
created 2008, modified 2018
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