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EC 3.1.1.106 Details
EC number
3.1.1.106
Accepted name
O-acetyl-ADP-ribose deacetylase
Reaction
(1) 3′′-O-acetyl-ADP-D-ribose + H2O = ADP-D-ribose + acetate;;(2) 2′′-O-acetyl-ADP-D-ribose + H2O = ADP-D-ribose + acetate
Other name(s)
ymdB (gene name), MACROD1 (gene name)
Systematic name
O-acetyl-ADP-D-ribose carboxylesterase
Comment
The enzyme, characterized from the bacterium Escherichia coli and from human cells, removes the acetyl group from either the 2′′ or 3′′ position of O-acetyl-ADP-ribose, which are formed by the action of EC 2.3.1.286, protein acetyllysine N-acetyltransferase. The human enzyme can also remove ADP-D-ribose from phosphorylated double stranded DNA adducts.
History
created 2019
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