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EC 3.5.4.36 Details
EC number
3.5.4.36
Accepted name
mRNA(cytosine6666) deaminase
Reaction
cytosine6666 in apolipoprotein B mRNA + H2O = uracil6666 in apolipoprotein B mRNA + NH3
Other name(s)
APOBEC-1 (catalytic component of an RNA-editing complex),
APOBEC1 (catalytic subunit),
apolipoprotein B mRNA-editing enzyme 1 (catalytic component of an RNA-editing complex),
apoB mRNA-editing enzyme catalytic polypeptide 1 (catalytic component of an RNA-editing complex),
apoB mRNA editing complex,
apolipoprotein B mRNA editing enzyme,
REPR
Systematic name
mRNA(cytosine6666) aminohydrolase
Comment
The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site [3].
History
created 2013
EC Tree
1.3.1.23 created 1972, deleted 2005
1.3.1.50 created 1992, deleted 1999
1.3.1.55 created 1999, deleted 2004