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EC 1.7.2.6 Details
EC number
1.7.2.6
Accepted name
hydroxylamine dehydrogenase
Reaction
hydroxylamine + H2O + 4 ferricytochrome c = nitrite + 4 ferrocytochrome c + 5 H+
Other name(s)
HAO (ambiguous), hydroxylamine oxidoreductase (ambiguous), hydroxylamine oxidase (misleading)
Systematic name
hydroxylamine:ferricytochrome-c oxidoreductase (nitrite-forming)
CAS registry number
9075-43-8
Comment
The enzymes from the nitrifying bacterium Nitrosomonas europaea [1,4] and the methylotrophic bacterium Methylococcus capsulatus [5] are hemoproteins with seven c-type hemes and one specialized P-460-type heme per subunit. The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate [3]. While nitrite is the main product, the enzyme from Nitrosomonas europaea can also produce nitric oxide by catalysing the activity of EC 1.7.2.9, hydroxylamine oxidase [2].
History
created 1972 as EC 1.7.3.4, part transferred 2012 to EC 1.7.2.6, modifed 2021, modified 2021
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