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EC 2.6.1.114 Details
show Brenda entryEC number
2.6.1.114
Accepted name
8-demethyl-8-aminoriboflavin-5′-phosphate synthase
Reaction
L-glutamate + FMN + O2 + H2O + 3 acceptor = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5′-phosphate + CO2 + 3 reduced acceptor (overall reaction);;(1a) FMN + O2 = 8-demethyl-8-formylriboflavin 5′-phosphate + H2O;;(1b) 8-demethyl-8-formylriboflavin 5′-phosphate + H2O + acceptor = 8-carboxy-8-demethylriboflavin 5′-phosphate + reduced acceptor;;(1c) L-glutamate + 8-carboxy-8-demethylriboflavin 5′-phosphate + H2O + 2 acceptor = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5′-phosphate + CO2 + 2 reduced acceptor
Other name(s)
rosB (gene name)
Systematic name
L-glutamate:FMN aminotransferase (oxidizing, decarboxylating)
Comment
The enzyme, characterized from the bacterium Streptomyces davawensis, has the activities of an oxidoreductase, a decarboxylase, and an aminotransferase. Its combined actions result in the replacement of a methyl substituent of one of the aromatic rings of FMN by an amino group, a step in the biosynthetic pathway of roseoflavin. The reaction requires thiamine for completion.
History
created 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.3.1 NAD(P)H oxidase (H2O2-forming)
