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EC 2.8.3.24 Details
show Brenda entryEC number
2.8.3.24
Accepted name
(R)-2-hydroxy-4-methylpentanoate CoA-transferase
Reaction
4-methylpentanoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpentanoate + (R)-2-hydroxy-4-methylpentanoyl-CoA
Other name(s)
hadA (gene name)
Systematic name
4-methylpentanoyl-CoA:(R)-2-hydroxy-4-methylpentanoate CoA-transferase
Comment
The enzyme, characterized from the bacterium Peptoclostridium difficile, participates in an L-leucine fermentation pathway. The reaction proceeds via formation of a covalent anhydride intermediate between a conserved aspartate residue and the acyl group of the CoA thioester substrate.
History
created 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003 1.14.17.2 created 1972, deleted 1984
