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EC 6.3.4.23 Details
show Brenda entryEC number
6.3.4.23
Accepted name
formate—phosphoribosylaminoimidazolecarboxamide ligase
Reaction
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
Other name(s)
5-formaminoimidazole-4-carboxamide ribonucleotide synthetase,
5-formaminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5′-monophosphate synthetase,
purP (gene name)
Systematic name
formate:5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide ligase (ADP-forming)
CAS registry number
9032-03-5
Comment
This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyses a step in the synthesis of purine nucleotides. It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. cf. EC 2.1.2.3, phosphoribosylaminoimidazolecarboxamide formyltransferase.
History
created 2013
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003 1.14.17.2 created 1972, deleted 1984
