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EC 6.3.1.15 Details
EC number
6.3.1.15
Accepted name
8-demethylnovobiocic acid synthase
Reaction
ATP + 4-hydroxy-3-prenylbenzoate + 3-amino-4,7-dihydroxycoumarin = AMP + diphosphate + 8-demethylnovobiocic acid
Other name(s)
novL (gene name),
novobiocin ligase,
novobiocic acid synthetase (misleading),
8-desmethyl-novobiocic acid synthetase,
8-demethylnovobiocic acid synthetase,
3-dimethylallyl-4-hydroxybenzoate:3-amino-4,7-dihydroxycoumarin ligase (AMP-forming)
Systematic name
4-hydroxy-3-prenylbenzoate:3-amino-4,7-dihydroxycoumarin ligase (AMP-forming)
Comment
The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin.
History
created 2013
EC Tree
1.14.13.45 created 1992, deleted 2003
1.14.17.2 created 1972, deleted 1984