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EC 1.1.1.330 Details
show Brenda entryEC number
1.1.1.330
Accepted name
very-long-chain 3-oxoacyl-CoA reductase
Reaction
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + NADPH + H+
Other name(s)
very-long-chain 3-ketoacyl-CoA reductase,
very-long-chain β-ketoacyl-CoA reductase,
KCR (gene name),
IFA38 (gene name)
Systematic name
(3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase
Comment
The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.
History
created 2012
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003 1.14.17.2 created 1972, deleted 1984
