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EC 1.14.14.9 Details
EC number
1.14.14.9
Accepted name
4-hydroxyphenylacetate 3-monooxygenase
Reaction
4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O
Other name(s)
p-hydroxyphenylacetate 3-hydroxylase, 4-hydroxyphenylacetic acid-3-hydroxylase, p-hydroxyphenylacetate hydroxylase (FAD), 4 HPA 3-hydroxylase, p-hydroxyphenylacetate 3-hydroxylase (FAD), HpaB
Systematic name
4-hydroxyphenylacetate,FADH2:oxygen oxidoreductase (3-hydroxylating)
CAS registry number
37256-71-6
Comment
The enzyme from Escherichia coli attacks a broad spectrum of phenolic compounds. The enzyme uses FADH2 as a substrate rather than a cofactor [4]. FADH2 is provided by EC 1.5.1.36, flavin reductase (NADH) [5,6].
History
created 1972 as EC 1.14.13.3, transferred 2011 to EC 1.14.14.9
EC Tree
1.14.13.45 created 1992, deleted 2003
1.14.17.2 created 1972, deleted 1984