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EC 1.14.12.12 Details
EC number
1.14.12.12
Accepted name
naphthalene 1,2-dioxygenase
Reaction
naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+
Other name(s)
naphthalene dioxygenase, naphthalene oxygenase, NDO
Systematic name
naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
CAS registry number
9074-04-8
Comment
This enzyme is a member of the ring-hydroxylating dioxygenase (RHD) family of bacterial enzymes that play a critical role in the degradation of aromatic compounds, such as polycyclic aromatic hydrocarbons [5]. This enzyme comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.3, ferredoxin—NAD+ reductase), an iron-sulfur oxygenase, and ferredoxin. Requires Fe2+.
History
created 1992
EC Tree
1.14.13.45 created 1992, deleted 2003
1.14.17.2 created 1972, deleted 1984