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EC 6.3.2.40 Details
EC number
6.3.2.40
Accepted name
cyclopeptine synthase
Reaction
2 ATP + S-adenosyl-L-methionine + anthranilate + L-phenylalanine = cyclopeptine + 2 AMP + 2 diphosphate + S-adenosyl-L-homocysteine
Systematic name
S-adenosyl-L-methionine:anthranilate:L-phenylalanine ligase (cyclopeptine-forming)
Comment
Cyclopeptine synthase is the key enzyme of benzodiazepine alkaloid biosynthesis in the fungus Penicillium cyclopium. The enzyme is a non-ribosomal peptide synthase.
History
created 2013
EC Tree
1.14.11.5 created 1972, deleted 1976
1.14.17.2 created 1972, deleted 1984