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EC 1.5.1.43 Details
show Brenda entryEC number
1.5.1.43
Accepted name
carboxynorspermidine synthase
Reaction
(1) carboxynorspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+;;(2) carboxyspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + putrescine + NADPH + H+
Other name(s)
carboxynorspermidine dehydrogenase,
carboxyspermidine dehydrogenase,
CASDH,
CANSDH,
VC1624 (gene name)
Systematic name
carboxynorspermidine:NADP+ oxidoreductase
Comment
The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively [1]. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation [2]. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro [3].
History
created 2012
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.7.1 created 1972, deleted 1978 1.6.7.2 created 1972, deleted 1978 1.6.7.3 created 1978, deleted 1978
