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EC 1.7.2.6 Details
EC number
1.7.2.6
Accepted name
hydroxylamine dehydrogenase
Reaction
hydroxylamine + H2O + 4 ferricytochrome c = nitrite + 4 ferrocytochrome c + 5 H+
Other name(s)
HAO (ambiguous), hydroxylamine oxidoreductase (ambiguous), hydroxylamine oxidase (misleading)
Systematic name
hydroxylamine:ferricytochrome-c oxidoreductase (nitrite-forming)
CAS registry number
9075-43-8
Comment
The enzymes from the nitrifying bacterium Nitrosomonas europaea [1,4] and the methylotrophic bacterium Methylococcus capsulatus [5] are hemoproteins with seven c-type hemes and one specialized P-460-type heme per subunit. The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate [3]. While nitrite is the main product, the enzyme from Nitrosomonas europaea can also produce nitric oxide by catalysing the activity of EC 1.7.2.9, hydroxylamine oxidase [2].
History
created 1972 as EC 1.7.3.4, part transferred 2012 to EC 1.7.2.6, modifed 2021, modified 2021
EC Tree
1.6.7.1 created 1972, deleted 1978
1.6.7.2 created 1972, deleted 1978
1.6.7.3 created 1978, deleted 1978