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EC 1.3.1.114 Details
EC number
1.3.1.114
Accepted name
3-dehydro-bile acid Δ4,6-reductase
Reaction
(1) 3-oxocholan-24-oyl-CoA + NAD+ = 3-oxochol-4-en-24-oyl-CoA + NADH + H+;;(2) 3-oxochol-4-en-24-oyl-CoA + NAD+ = 3-oxochol-4,6-dien-24-oyl-CoA + NADH + H+;;(3) 12α-hydroxy-3-oxocholan-24-oyl-CoA + NAD+ = 12α-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+;;(4) 12α-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD+ = 12α-hydroxy-3-oxochol-4,6-dien-24-oyl-CoA + NADH + H+;;
Other name(s)
baiN (gene name)
Systematic name
3-oxocholan-24-oyl-CoA Δ4,6-oxidoreductase
Comment
Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7α-dehydroxylation pathway. The enzyme catalyses two subsequent reductions of the double bonds within the bile acid A/B rings, following 7α-dehydration.
History
created 2018
EC Tree
1.6.5.1 created 1961, deleted 1965
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002