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EC 2.4.2.60 Details
show Brenda entryEC number
2.4.2.60
Accepted name
cysteine-dependent adenosine diphosphate thiazole synthase
Reaction
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O
Other name(s)
THI4 (gene name) (ambiguous),
THI1 (gene name),
ADP-thiazole synthase
Systematic name
NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing)
Comment
This iron dependent enzyme, found in fungi, plants, and some archaea, is involved in the thiamine phosphate biosynthesis pathway. It is a single turn-over enzyme since the cysteine residue is not regenerated in vivo [3]. The homologous enzyme in archaea (EC 2.4.2.59, sulfide-dependent adenosine diphosphate thiazole synthase) uses sulfide as sulfur donor.
History
created 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.5.1 created 1961, deleted 1965 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
