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EC 2.4.2.59 Details
EC number
2.4.2.59
Accepted name
sulfide-dependent adenosine diphosphate thiazole synthase
Reaction
NAD+ + glycine + sulfide = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O
Other name(s)
Thi4 (ambiguous)
Systematic name
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Comment
This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. The homologous enzyme from plants and fungi (EC 2.4.2.60, cysteine-dependent adenosine diphosphate thiazole synthase) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.
History
created 2018
EC Tree
1.6.5.1 created 1961, deleted 1965
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002