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EC 6.2.1.49 Details
EC number
6.2.1.49
Accepted name
long-chain fatty acid adenylyltransferase FadD28
Reaction
ATP + a long-chain fatty acid + holo-[mycocerosate synthase] = AMP + diphosphate + a long-chain acyl-[mycocerosate synthase] (overall reaction);;(1a) ATP + a long-chain fatty acid = diphosphate + a long-chain acyl-adenylate ester;;(1b) a long-chain acyl-adenylate ester + holo-[mycocerosate synthase] = AMP + a long-chain acyl-[mycocerosate synthase]
Other name(s)
fadD28 (gene name)
Systematic name
long-chain fatty acid:holo-[mycocerosate synthase] ligase (AMP-forming)
Comment
The enzyme, found in certain mycobacteria, activates long-chain fatty acids by adenylation and transfers them to EC 2.3.1.111, mycocerosate synthase. The enzyme participates in the biosynthesis of the virulent lipids dimycocerosates (DIM) and dimycocerosyl triglycosyl phenolphthiocerol (PGL).
History
created 2016 as EC 2.7.7.95, transferred 2017 to EC 6.2.1.49
EC Tree
1.6.5.1 created 1961, deleted 1965
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002