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EC 6.3.2.49 Details
EC number
6.3.2.49
Accepted name
L-alanine—L-anticapsin ligase
Reaction
ATP + L-alanine + L-anticapsin = ADP + phosphate + bacilysin
Other name(s)
BacD, alanine-anticapsin ligase, L-Ala-L-anticapsin ligase, ywfE (gene name)
Systematic name
L-alanine:L-anticapsin ligase (ADP-forming)
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme requires Mg2+ or Mn2+ for activity, and has a broad substrate specificity in vitro [1].
History
created 2006 as EC 6.3.2.28, transferred 2015 to EC 6.3.2.49
EC Tree
1.6.5.1 created 1961, deleted 1965
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002