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EC 1.14.21.4 Details
EC number
1.14.21.4
Accepted name
salutaridine synthase
Reaction
(R)-reticuline + NADPH + H+ + O2 = salutaridine + NADP+ + 2 H2O
Other name(s)
(R)-reticuline oxidase (C-C phenol-coupling)
Systematic name
(R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)
CAS registry number
149433-84-1
Comment
A heme-thiolate enzyme (P-450). Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.
History
created 2002, deleted 2018
EC Tree
1.14.99.5 created 1972, modified 1986, modified 2000, deleted 2000
1.14.99.6 created 1972, modified 2000, deleted 2000
1.14.99.8 created 1972, deleted 1984
1.14.99.13 created 1972, deleted 1984
1.14.99.16 created 1972, deleted 2002
1.14.99.17 created 1972, deleted 1976
1.14.99.18 created 1976, modified 1999, deleted 2003
1.14.99.25 created 1986, deleted 2000