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EC 1.14.17.1 Details
EC number
1.14.17.1
Accepted name
dopamine β-monooxygenase
Reaction
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O
Other name(s)
dopamine β-hydroxylase, MDBH (membrane-associated dopamine β-monooxygenase), SDBH (soluble dopamine β-monooxygenase), dopamine-B-hydroxylase, 3,4-dihydroxyphenethylamine β-oxidase, 4-(2-aminoethyl)pyrocatechol β-oxidase, dopa β-hydroxylase, dopamine β-oxidase, dopamine hydroxylase, phenylamine β-hydroxylase, (3,4-dihydroxyphenethylamine)β-mono-oxygenase, DβM (gene name)
Systematic name
dopamine,ascorbate:oxygen oxidoreductase (β-hydroxylating)
CAS registry number
9013-38-1
Comment
A copper protein. The enzyme, found in animals, binds two copper ions with distinct roles during catalysis. Stimulated by fumarate.
History
created 1965 as EC 1.14.2.1, transferred 1972 to EC 1.14.17.1, modified 2020
EC Tree
1.14.99.5 created 1972, modified 1986, modified 2000, deleted 2000
1.14.99.6 created 1972, modified 2000, deleted 2000
1.14.99.8 created 1972, deleted 1984
1.14.99.13 created 1972, deleted 1984
1.14.99.16 created 1972, deleted 2002
1.14.99.17 created 1972, deleted 1976
1.14.99.18 created 1976, modified 1999, deleted 2003
1.14.99.25 created 1986, deleted 2000