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EC 1.14.16.4 Details
show Brenda entryEC number
1.14.16.4
Accepted name
tryptophan 5-monooxygenase
Reaction
L-tryptophan + a 5,6,7,8-tetrahydropteridine + O2 = 5-hydroxy-L-tryptophan + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
Other name(s)
L-tryptophan hydroxylase,
indoleacetic acid-5-hydroxylase,
tryptophan 5-hydroxylase,
tryptophan hydroxylase
Systematic name
L-tryptophan,tetrahydropteridine:oxygen oxidoreductase (5-hydroxylating)
CAS registry number
9037-21-2
Comment
The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by a Ca2+-activated protein kinase. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.
History
created 1972, modified 2003, modified 2019
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.21.1 (S)-stylopine synthase
