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EC 1.14.11.49 Details
EC number
1.14.11.49
Accepted name
uridine-5′-phosphate dioxygenase
Reaction
UMP + 2-oxoglutarate + O2 = 5′-dehydrouridine + succinate + CO2 + phosphate
Other name(s)
lipL (gene name)
Systematic name
UMP,2-oxoglutarate:oxygen oxidoreductase
Comment
The enzyme catalyses a net dephosphorylation and oxidation of UMP to generate 5′-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C7-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. Requires Fe2+.
History
created 2015
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