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EC 1.14.18.5 Details
show Brenda entryEC number
1.14.18.5
Accepted name
sphingolipid C4-monooxygenase
Reaction
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4R)-4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O
Other name(s)
sphinganine C4-monooxygenase,
sphingolipid C4-hydroxylase,
SUR2 (gene name),
SBH1 (gene name),
SBH2 (gene name),
DEGS2 (gene name)
Systematic name
dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
Comment
The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase [4].
History
created 2012 as EC 1.14.13.169, transferred 2015 to EC 1.14.18.5
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.19.1 stearoyl-CoA 9-desaturase
