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EC 1.14.13.95 Details
EC number
1.14.13.95
Accepted name
7α-hydroxycholest-4-en-3-one 12α-hydroxylase
Reaction
7α-hydroxycholest-4-en-3-one + NADPH + H+ + O2 = 7α,12α-dihydroxycholest-4-en-3-one + NADP+ + H2O
Other name(s)
7α-hydroxy-4-cholesten-3-one 12α-monooxygenase, CYP12, sterol 12α-hydroxylase (ambiguous), HCO 12α-hydroxylase
Systematic name
7α-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12α-hydroxylating)
Comment
A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH—hemoprotein reductase, which reduced cytochrome b5 at the expense of NADPH. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid [2].
History
created 2005, deleted 2015
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