EC Explorer

7.2.4.3

(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)

(S)-methylmalonyl-CoA + Na⁺_{[side 1]} + H⁺_{[side 2]} = propanoyl-CoA + CO₂ + Na⁺_{[side 2]}

methylmalonyl-coenzyme A decarboxylase (ambiguous), (S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase (incorrect), (S)-methylmalonyl-CoA carboxy-lyase (ambiguous)

(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming, sodium-transporting)

37289-44-4

This bacterial enzyme couples the decarboxylation of (S)-methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na⁺ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis. It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity.

created 1972 as EC 4.1.1.41, modified 1983, modified 1986, transferred 2018 to EC 7.2.4.3