EC Explorer

7.2.4.1

carboxybiotin decarboxylase

a carboxybiotinyl-[protein] + n Na⁺_{[side 1]} + H⁺_{[side 2]} = CO₂ + a biotinyl-[protein] + n Na⁺_{[side 2]} (n = 1–2)

MadB, carboxybiotin protein decarboxylase

carboxybiotinyl-[protein] carboxy-lyase

The integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase. The free energy of the decarboxylation reaction is used to pump Na⁺ out of the cell. The enzyme is a member of the Na⁺-translocating decarboxylase family, other members of which include EC 7.2.4.2 [oxaloacetate decarboxylase (Na⁺ extruding)] and EC 7.2.4.3 [(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)] [2].

created 2008 as EC 4.3.99.2, transferred 2018 to EC 7.2.4.1