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EC 2.4.1.356 Details
EC number
2.4.1.356
Accepted name
glucosyl-dolichyl phosphate glucuronosyltransferase
Reaction
UDP-α-D-glucuronate + an archaeal dolichyl α-D-glucosyl phosphate = UDP + an archaeal dolichyl β-D-glucuronosyl-(1→4)-α-D-glucosyl phosphate
Other name(s)
aglG (gene name)
Systematic name
UDP-α-D-glucuronate:dolichyl phosphate glucuronosyltransferase (configuration-inverting)
Comment
The enzyme, characterized from the halophilic archaeon Haloferax volcanii, participates in the protein N-glycosylation pathway. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60) and is α,ω-saturated. However, in vitro the enzyme was also able to act on a substrate with an unsaturated end.
History
created 2018
EC Tree
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002