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EC 4.3.2.9 Details
EC number
4.3.2.9
Accepted name
γ-glutamylcyclotransferase
Reaction
α-(γ-L-glutamyl)-L-amino acid = α-L-amino acid + 5-oxo-L-proline
Other name(s)
γ-glutamyl-amino acid cyclotransferase,
γ-L-glutamylcyclotransferase,
L-glutamic cyclase,
(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing),
GGCT
Systematic name
α-(γ-L-glutamyl)-L-amino-acid γ-glutamyl cyclotransferase (5-oxo-L-proline producing)
CAS registry number
9045-44-7
Comment
The enzyme, found in animals and plants, acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
History
created 1972 as EC 2.3.2.4, transferred 2017 to EC 4.3.2.9
EC Tree
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002