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EC 6.3.2.48 Details
EC number
6.3.2.48
Accepted name
L-arginine-specific L-amino acid ligase
Reaction
ATP + L-arginine + an L-amino acid = ADP + phosphate + an L-arginyl-L-amino acid
Other name(s)
RizA, L-amino acid ligase RizA
Systematic name
L-arginine:L-amino acid ligase (ADP-forming)
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, requires Mn2+ for activity. It shows strict substrate specificity toward L-arginine as the first (N-terminal) amino acid of the product. The second amino acid could be any standard protein-building amino acid except for L-proline.
History
created 2015
EC Tree
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002