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EC 4.2.3.98 Details
show Brenda entryEC number
4.2.3.98
Accepted name
(+)-T-muurolol synthase
Reaction
(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate
Systematic name
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-T-muurolol-forming)
Comment
The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original 1-pro-S hydrogen of farnesyl diphosphate, cyclization and deprotonation result in (+)-T-muurolol.
History
created 2012
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
