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EC 1.14.19.6 Details
EC number
1.14.19.6
Accepted name
acyl-CoA (9+3)-desaturase
Reaction
(1) oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O;;(2) palmitoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (9Z,12Z)-hexadeca-9,12-dienoyl-CoA + 2 ferricytochrome b5 + 2 H2O
Other name(s)
oleoyl-CoA 12-desaturase, Δ12 fatty acid desaturase, Δ126)-desaturase, oleoyl-CoA Δ12 desaturase, Δ12 desaturase, Δ12-desaturase, Δ12-fatty-acid desaturase, acyl-CoA,hydrogen donor:oxygen Δ12-oxidoreductase
Systematic name
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (12,13 cis-dehydrogenating)
Comment
This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. When acting on 19:1Δ10 fatty acyl-CoA the enzyme from the pathogenic protozoan Trypanosoma brucei introduces the new double bond at position 13, indicating that the new double bond is introduced three carbons from the existing cis double bond, towards the methyl-end of the fatty acid. Requires cytochrome b5 as the electron donor [4].
History
created 2008, modified 2015
EC Tree
1.14.13.45 created 1992, deleted 2003