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EC 1.14.13.83 Details
show Brenda entryEC number
1.14.13.83
Accepted name
precorrin-3B synthase
Reaction
precorrin-3A + NADH + H+ + O2 = precorrin-3B + NAD+ + H2O
Other name(s)
precorrin-3X synthase,
CobG
Systematic name
precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)
CAS registry number
152787-63-8
Comment
An iron-sulfur protein. An oxygen atom from dioxygen is incorporated into the macrocycle at C-20. In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively.
History
created 2004
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
