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EC 1.14.13.50 Details
EC number
1.14.13.50
Accepted name
pentachlorophenol monooxygenase
Reaction
(1) pentachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O;;(2) 2,3,5,6-tetrachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachlorohydroquinone + NADP+ + H2O
Other name(s)
pcpB (gene name), pentachlorophenol dechlorinase, pentachlorophenol dehalogenase, pentachlorophenol 4-monooxygenase, PCP hydroxylase, pentachlorophenol hydroxylase, PCB 4-monooxygenase, PCB4MO
Systematic name
pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)
CAS registry number
136111-57-4
Comment
A flavoprotein (FAD). The enzyme displaces a diverse range of substituents from the 4-position of polyhalogenated phenols but requires that a halogen substituent be present at the 2-position [2]. If C-4 carries a halogen substituent, reaction 1 is catalysed; if C-4 is unsubstituted, reaction 2 is catalysed.
History
created 1992, modified 2005, modified 2017
EC Tree
1.14.13.45 created 1992, deleted 2003