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EC 1.14.12.18 Details
EC number
1.14.12.18
Accepted name
biphenyl 2,3-dioxygenase
Reaction
biphenyl + NADH + H+ + O2 = (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
Other name(s)
biphenyl dioxygenase
Systematic name
biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)
CAS registry number
103289-55-0
Comment
Requires Fe2+. The enzyme from Burkholderia fungorum LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske-type iron-sulfur cluster and a catalytic mononuclear nonheme iron centre. Chlorine-substituted biphenyls can also act as substrates. Similar to the three-component enzyme systems EC 1.14.12.3 (benzene 1,2-dioxygenase) and EC 1.14.12.11 (toluene dioxygenase).
History
created 2001
EC Tree
1.14.13.45 created 1992, deleted 2003