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EC 4.1.3.39 Details
EC number
4.1.3.39
Accepted name
4-hydroxy-2-oxovalerate aldolase
Reaction
(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate
Other name(s)
4-hydroxy-2-ketovalerate aldolase, HOA, DmpG, 4-hydroxy-2-oxovalerate pyruvate-lyase, 4-hydroxy-2-oxopentanoate pyruvate-lyase, BphI, 4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
Systematic name
(S)-4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
CAS registry number
37325-52-3
Comment
Requires Mn2+ for maximal activity [1]. The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH [1]. In some bacterial species the enzyme forms a bifunctional complex with EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase [4,5].
History
created 2006, modified 2011
EC Tree
1.14.11.5 created 1972, deleted 1976