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EC 1.13.99.3 Details
EC number
1.13.99.3
Accepted name
tryptophan 2′-dioxygenase
Reaction
L-tryptophan + O2 = (indol-3-yl)glycolaldehyde + CO2 + NH3
Other name(s)
indole-3-alkane α-hydroxylase, tryptophan side-chain α,β-oxidase, tryptophan side chain oxidase II, tryptophan side-chain oxidase, TSO, indolyl-3-alkan α-hydroxylase, tryptophan side chain oxidase type I, TSO I , TSO II, tryptophan side chain oxidase
Systematic name
L-tryptophan:oxygen 2′-oxidoreductase (side-chain-cleaving)
CAS registry number
64295-81-4
Comment
A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2′-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.
History
created 1984
EC Tree
1.14.11.5 created 1972, deleted 1976