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EC 1.14.19.67 Details
EC number
1.14.19.67
Accepted name
salutaridine synthase
Reaction
(R)-reticuline + [reduced NADPH—hemoprotein reductase] + O2 = salutaridine + [oxidized NADPH—hemoprotein reductase] + 2 H2O
Other name(s)
(R)-reticuline oxidase (C-C phenol-coupling)
Systematic name
(R)-reticuline,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (C-C phenol-coupling)
CAS registry number
149433-84-1
Comment
A cytochrome P-450 (heme-thiolate) protein found in plants. Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.
History
created 1999 as EC 1.1.3.35, transferred 2002 to EC 1.14.21.4, transferred 2018 to EC 1.14.19.67
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