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EC 1.5.4.1 Details
EC number
1.5.4.1
Accepted name
pyrimidodiazepine synthase
Reaction
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione
Other name(s)
PDA synthase, pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing), pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Systematic name
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
CAS registry number
93586-06-2
Comment
In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.
History
created 1990, modified 2014
EC Tree
1.6.7.1 created 1972, deleted 1978
1.6.7.2 created 1972, deleted 1978
1.6.7.3 created 1978, deleted 1978