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EC 1.13.11.65 Details
EC number
1.13.11.65
Accepted name
carotenoid isomerooxygenase
Reaction
zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal
Other name(s)
ninaB (gene name)
Systematic name
zeaxanthin:oxygen 15,15′-oxidoreductase (bond-cleaving, cis-isomerizing)
Comment
The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary caroteoids in insects. The enzyme accepts different all-trans carotenoids, including β-carotene, α-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule.
History
created 2012 as EC 1.14.13.164, transferred 2012 to EC 1.13.11.65
EC Tree
1.6.7.1 created 1972, deleted 1978
1.6.7.2 created 1972, deleted 1978
1.6.7.3 created 1978, deleted 1978