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EC 3.6.1.62 Details
EC number
3.6.1.62
Accepted name
5′-(N7-methylguanosine 5′-triphospho)-[mRNA] hydrolase
Reaction
a 5′-(N7-methylguanosine 5′-triphospho)-[mRNA] + H2O = N7-methylguanosine 5′-diphosphate + a 5′-phospho-[mRNA]
Other name(s)
Dcp2, NUDT16, D10 protein, D9 protein, D10 decapping enzyme, decapping enzyme, m7GpppN-mRNA hydrolase, m7GpppN-mRNA m7GDP phosphohydrolase
Systematic name
5′-(N7-methylguanosine 5′-triphospho)-[mRNA] N7-methylguanosine-5′-diphosphate phosphohydrolase
Comment
Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) [3]. The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ [5].
History
created 2012, modified 2013
EC Tree
1.1.1.68 created 1965, deleted 1978 [transferred to EC 1.1.99.15, deleted 1980]
1.1.1.70 created 1965, deleted 1978
1.1.1.74 created 1972, deleted 1976
1.1.1.89 created 1972, deleted 1976
1.1.1.109 created 1972, deleted 1976
1.1.1.139 created 1972, deleted 1978
1.1.1.155 created 1976, deleted 2004
1.1.1.171 created 1978, deleted 1984
1.1.1.180 created 1983, deleted 1984
1.1.1.182 created 1983, deleted 1990
1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004
1.1.1.242 created 1992, deleted 2001
1.1.1.249 provisional version created 1999, deleted 1999 (reinstated 2001 as EC 2.5.1.46)
1.1.1.253 created 1999, deleted 2003
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003