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EC 1.14.13.113 Details
EC number
1.14.13.113
Accepted name
FAD-dependent urate hydroxylase
Reaction
urate + NADH + H+ + O2 = 5-hydroxyisourate + NAD+ + H2O
Other name(s)
HpxO enzyme, FAD-dependent urate oxidase, urate hydroxylase
Systematic name
urate,NADH:oxygen oxidoreductase (5-hydroxyisourate-forming)
Comment
A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC 1.7.3.3, factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC 3.5.2.17, hydroxyisourate hydrolase.
History
created 2010
EC Tree
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003