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EC 4.1.1.98 Details

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EC number

4.1.1.98

Accepted name

4-hydroxy-3-polyprenylbenzoate decarboxylase

Reaction

a 4-hydroxy-3-polyprenylbenzoate = a 2-polyprenylphenol + CO₂

Other name(s)

ubiD (gene name), 4-hydroxy-3-solanesylbenzoate decarboxylase, 3-octaprenyl-4-hydroxybenzoate decarboxylase

Systematic name

4-hydroxy-3-polyprenylbenzoate carboxy-lyase

Comment

The enzyme catalyses a step in prokaryotic ubiquinone biosynthesis, as well as in plastoquinone biosynthesis in cyanobacteria. The enzyme can accept substrates with different polyprenyl tail lengths in vitro, but uses a specific length in vivo, which is determined by the polyprenyl diphosphate synthase that exists in the specific organism. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.

History

created 2014, modified 2015

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.1.99.1 choline dehydrogenase

1.1.99.2 L-2-hydroxyglutarate dehydrogenase

1.1.99.3 gluconate 2-dehydrogenase (acceptor)

1.1.99.4 dehydrogluconate dehydrogenase

1.1.99.5 glycerol-3-phosphate dehydrogenase

1.1.99.6 D-lactate dehydrogenase (acceptor)

1.1.99.7 lactate—malate transhydrogenase

1.1.99.8 alcohol dehydrogenase (acceptor)

1.1.99.9 pyridoxine 5-dehydrogenase

1.1.99.10 glucose dehydrogenase (acceptor)

1.1.99.11 fructose 5-dehydrogenase

1.1.99.12 sorbose dehydrogenase

1.1.99.13 glucoside 3-dehydrogenase (acceptor)

1.1.99.14 glycolate dehydrogenase

1.1.99.15 created 1978, deleted 1980

1.1.99.16 malate dehydrogenase (acceptor)

1.1.99.17 created 1982, deleted 2003

1.1.99.18 cellobiose dehydrogenase (acceptor)

1.1.99.19 uracil dehydrogenase

1.1.99.20 alkan-1-ol dehydrogenase (acceptor)

1.1.99.21 D-sorbitol dehydrogenase (acceptor)

1.1.99.22 glycerol dehydrogenase (acceptor)

1.1.99.23 polyvinyl-alcohol dehydrogenase (acceptor)

1.1.99.24 hydroxyacid-oxoacid transhydrogenase

1.1.99.25 quinate dehydrogenase (pyrroloquinoline-quinone)

1.1.99.26 3-hydroxycyclohexanone dehydrogenase

1.1.99.27 (R)-pantolactone dehydrogenase (flavin)

1.1.99.28 glucose-fructose oxidoreductase

1.1.99.29 pyranose dehydrogenase (acceptor)

1.1.99.30 2-oxo-acid reductase

1.1.99.31 (S)-mandelate dehydrogenase

1.1.99.32 L-sorbose 1-dehydrogenase

1.1.99.33 formate dehydrogenase (acceptor)

1.1.99.34 glucose-6-phosphate dehydrogenase (coenzyme-F₄₂₀)

1.1.99.35 soluble quinoprotein glucose dehydrogenase

1.1.99.36 alcohol dehydrogenase (nicotinoprotein)

1.1.99.37 methanol dehydrogenase (nicotinoprotein)

1.1.99.38 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)

1.1.99.39 D-2-hydroxyglutarate dehydrogenase

1.1.99.40 (R)-2-hydroxyglutarate—pyruvate transhydrogenase

1.1.99.41 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase

1.1.99.42 4-pyridoxic acid dehydrogenase

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.3 With oxygen as acceptor

1.5.4 With a disulfide as acceptor

1.5.5 With a quinone or similar compound as acceptor

1.5.7 With an iron-sulfur protein as acceptor

1.5.8 With a flavin or flavoprotein as acceptor

1.5.98 With other, known, physiological acceptors

1.5.99 With unknown physiological acceptors

1.5.99.1 sarcosine dehydrogenase

1.5.99.2 dimethylglycine dehydrogenase

1.5.99.3 L-pipecolate dehydrogenase

1.5.99.4 nicotine dehydrogenase

1.5.99.5 methylglutamate dehydrogenase

1.5.99.6 spermidine dehydrogenase

1.5.99.7 created 1976, deleted 2002

1.5.99.8 proline dehydrogenase

1.5.99.9 methylenetetrahydromethanopterin dehydrogenase

1.5.99.10 created 1999, deleted 2002

1.5.99.11 5,10-methylenetetrahydromethanopterin reductase

1.5.99.12 cytokinin dehydrogenase

1.5.99.13 D-proline dehydrogenase

1.5.99.14 6-hydroxypseudooxynicotine dehydrogenase

1.5.99.15 dihydromethanopterin reductase (acceptor)

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)