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EC 4.3.2.6 Details
EC number
4.3.2.6
Accepted name
γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase
Reaction
γ-L-glutamyl-butirosin B = butirosin B + 5-oxo-L-proline
Other name(s)
btrG (gene name), γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxoproline producing)
Systematic name
γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxo-L-proline producing)
Comment
The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the terminal γ-L-glutamate of the side chain, releasing it as the cyclic 5-oxo-L-proline.
History
created 2012
EC Tree
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003
1.5.1.4 created 1961, deleted 1976
1.5.1.13 created 1972, deleted 2004
1.5.1.14 created 1976, deleted 1989