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EC 1.5.1.12 Details
show Brenda entryEC number
1.5.1.12
Accepted name
1-pyrroline-5-carboxylate dehydrogenase
Reaction
L-glutamate γ-semialdehyde + NAD+ + H2O = L-glutamate + NADH + H+
Other name(s)
Δ1-pyrroline-5-carboxylate dehydrogenase,
1-pyrroline dehydrogenase,
pyrroline-5-carboxylate dehydrogenase,
pyrroline-5-carboxylic acid dehydrogenase,
L-pyrroline-5-carboxylate-NAD+ oxidoreductase,
1-pyrroline-5-carboxylate:NAD+ oxidoreductase,
Δ1-pyrroline-5-carboxylic acid dehydrogenase
Systematic name
L-glutamate γ-semialdehyde:NAD+ oxidoreductase
CAS registry number
9054-82-4
Comment
This enzyme catalyses the irreversible oxidation of glutamate-γ-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.99.8, proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate γ-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP+ can also act as acceptor, but with lower activity [5].
History
created 1972, modified 2008, deleted 2013
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003 1.5.1.4 created 1961, deleted 1976 1.5.1.13 created 1972, deleted 2004 1.5.1.14 created 1976, deleted 1989
