Any feedback?
Please rate this page
(ecexplorer.php)
(0/150)

BRENDA support

EC Explorer

EC 1.1.1.284 Details
EC number
1.1.1.284
Accepted name
S-(hydroxymethyl)glutathione dehydrogenase
Reaction
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+
Other name(s)
NAD-linked formaldehyde dehydrogenase (incorrect), formaldehyde dehydrogenase (incorrect), formic dehydrogenase (incorrect), class III alcohol dehydrogenase, ADH3, χ-ADH, FDH (incorrect), formaldehyde dehydrogenase (glutathione) (incorrect), GS-FDH (incorrect), glutathione-dependent formaldehyde dehydrogenase (incorrect), GD-FALDH, NAD- and glutathione-dependent formaldehyde dehydrogenase, NAD-dependent formaldehyde dehydrogenase (incorrect)
Systematic name
S-(hydroxymethyl)glutathione:NAD+ oxidoreductase
Comment
The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase. This enzyme forms part of the pathway that detoxifies formaldehyde, since the product is hydrolysed by EC 3.1.2.12, S-formylglutathione hydrolase. The human enzyme belongs to the family of zinc-dependent alcohol dehydrogenases. Also specifically reduces S-nitrosylglutathione.
History
created 2005 (EC 1.2.1.1 created 1961, modified 1982, modified 2002, part transferred 2005 to EC 1.1.1.284)
EC Tree
1.1.3.1 created 1961, deleted 1984
1.1.3.22 created 1961 as EC 1.2.3.2, transferred 1984 to EC 1.1.3.22, modified 1989, deleted 2004
1.1.3.25 created 1986, deleted 2005
1.1.3.26 created 1989, deleted 2002
1.1.3.31 created 1992, deleted 2003
1.1.3.32 created 1999, deleted 2002
1.1.3.33 created 1999, deleted 2002
1.1.3.34 created 1999, deleted 2002
1.1.3.35 created 1999, deleted 2002
1.1.3.36 created 1999, deleted 2002
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003