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EC 1.1.1.283 Details
EC number
1.1.1.283
Accepted name
methylglyoxal reductase (NADPH)
Reaction
(S)-lactaldehyde + NADP+ = 2-oxopropanal + NADPH + H+
Other name(s)
lactaldehyde dehydrogenase (NADP+), GRE2 (gene name), methylglyoxal reductase (NADPH-dependent), lactaldehyde:NADP+ oxidoreductase
Systematic name
(S)-lactaldehyde:NADP+ oxidoreductase
CAS registry number
78310-66-4
Comment
The enzyme from the yeast Saccharomyces cerevisiae catalyses the reduction of a keto group in a number of compounds, forming enantiopure products. Among the substrates are methylglyoxal (which is reduced to (S)-lactaldehyde) [1,2], 3-methylbutanal [3], hexane-2,5-dione [4] and 3-chloro-1-phenylpropan-1-one [5]. The enzyme differs from EC 1.1.1.78, methylglyoxal reductase (NADH), which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference.
History
created 2005, modified 2013
EC Tree
1.1.3.1 created 1961, deleted 1984
1.1.3.22 created 1961 as EC 1.2.3.2, transferred 1984 to EC 1.1.3.22, modified 1989, deleted 2004
1.1.3.25 created 1986, deleted 2005
1.1.3.26 created 1989, deleted 2002
1.1.3.31 created 1992, deleted 2003
1.1.3.32 created 1999, deleted 2002
1.1.3.33 created 1999, deleted 2002
1.1.3.34 created 1999, deleted 2002
1.1.3.35 created 1999, deleted 2002
1.1.3.36 created 1999, deleted 2002
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003